Andrew has been on the comedy circuit for three years and has quickly excelled through the ranks to developing his first solo hour, the critically acclaimed sell-out show Andrew Doyle's Crash Course in Depravity at the 2011 Edinburgh Fringe Festival. He was a finalist in the 2010 Leicester Square New Comedian of the Year Award. He supported Scott Capurro on his UK tours in 2010 and 2011.

Andrew's other Edinburgh Fringe shows include Christie & Doyle's Axis of Evil (with Bridget Christie) at the Underbelly in 2005, The Holy Trinity in 2009 (with Joleed Farah and Ben Van Der Velde), Sex and Hugs and Forward Rolls in 2010 (with James Acaster and Ben Van Der Velde), and the Shakespearean farce Shamlet, which was a sell-out show in 2003, later transferring to the King's Head Theatre in London in 2006. He was also the principal writer on Pop Tarts, a sketch show which enjoyed a total sell-out run at the Pleasance Courtyard in 2003.

Andrew has also written two plays for BBC Radio 4: Jimmy Murphy Makes Amends (2008) and The Second Mr Bailey (2010). His stage play Borderland (2005) is published by Oberon Books.